and referring to msg 45277:

<<I will predict that the naked delivery of ZFs will soon be improved to result in a much better rate of GM, especially biallelic. And that would have HUGE implications for SGMO (IMHO it would utterly dwarf the impact of the Shire agreement - because those who understand the technology KNOW how huge it would be.) (Actually it would EXPAND the impact of the Shire agreement because it would greatly increase the number of disorders that ZFs would be effective for.)>>

Could you just explain that a bit for those who are not so acquainted with gene technology? What exactly are biallelic GMs?
And why would that have so huge positive implications for Sangamo?